Antihelicobacter Activity of a Flavonoid Compound Isolated from Desmostachya Bipinnata
نویسنده
چکیده
The study aimed to investigate the potential in vitro antihelicobacter activity of selected Egyptian plants, focusing on the determination of the main component responsible for such activity. The main objective is to obtain a natural product have antihelicobacter activity. Antimicrobial screening for wild Egyptian medicinal plant extracts, revealed that five methanolic extracts have good antihelicobacter activity. Determination of MICs, revealed that the wild plant, Desmostachya bipinnata (DEM) extract proved to be the most active one, where its MIC was 40 μg/ml. After fractionation of the DEM extract, ethyl acetate fraction exhibited excellent antihelicobacter activity. By further fractionation and purification, using TLC and column chromatography, a flavonoid compound was isolated, with MIC value of 62 μg/ml. The isolated compound was spectroscopically identified as 4`methoxy quercetin-7-O-glucoside. DEM plant (available as a wild plant in Egypt) containing a flavonoid compound which possesses a good in vitro antihelicobacter activity. The isolated compound (Quercetin) might be useful as a chemo-preventive agent for peptic ulcer in H. pylori-infected individuals, after its clinical valuation.
منابع مشابه
Evaluation of Antioxidant and DNA Damage Protection Activity of the Hydroalcoholic Extract of Desmostachya bipinnata L. Stapf
Desmostachya bipinnata Stapf (Poaceae/Gramineae) is an official drug of ayurvedic pharmacopoeia. Various parts of this plant were used extensively in traditional and folklore medicine to cure various human ailments. The present study was aimed to evaluate the antioxidant and DNA damage protection activity of hydroalcoholic extract of Desmostachya bipinnata both in vitro and in vivo, to provide ...
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